Dogoxin

DIGOXIN Indication:Atrial Fibrillation Normal dose: freight: 0.25mg every 2 hours IV or PO (max dose=1.5mg) maintenance: 0.125mg-0.375mg PO 0.125-0.25mg IV Geriatrics > 70yrs with good renal function should be smashed with 0.5mg x2 doses and maintained with 0.125mg PO formerly daily. The patient in this fictitious character is a 72yo who was stipulation 0.5mg IV two hours apart (instead of the recommended half a cardinal hours apart) with a maintenance dose of 0.125mg daily. Therapeutic serum fellate=0.8-2ng/mL Time to peak= 1-3 hours T ½= 1.5-2 days quest the two fill doses, the patient had a digoxin orchestrate of 1.5ng/mL. Two days, and two doses later, the patient was bradycardic and hypotensive with a digoxin level of 1.9ng/mL. digoxin was stopped and after 15 hours the digoxin level dropped to 1.2ng/mL. digoxin works by inhibiting Na+/K+ ATPase, which causes and increase in intracellular Na+ concentration and hatful running to hy perkalemia and hypercalcemia. This in turn can lead to archeozoic afterdepolarization, cardiac irritability, and dysrhythmias. As vagal tad increases and sympathetic tone decreases it can lead to bradycardia and heartblock.

The most common symptoms of digoxin toxicity are: slap-upnausea, vomiting, abdominal pain, lethargy, bradycardia Chronicbradycardia, malaise, nausea, anorexia, delirium, vision changes unforgivingbradycardia, heartblock, vomiting, shock, hyperkalemia If potassium level is > 5mEq/L with symptomatic bradycardia, digoxin toxicity should be hardened with Digoxin Immune Fab, which works by binding digoxin molecules and helps to eliminate them from the body . Each vial of DIGIBIND entrust bind with! 0.5mg of digoxin. References: Micromedex dose study App Thomson Reuters Goodman and Gilmans DIGIBIND Drug Information Leaflet McGraw Hill Diagnosis and TreatmentIf you privation to get a full essay, order it on our website: OrderEssay.net

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